Development of a schistosomiasis vaccine
نویسندگان
چکیده
منابع مشابه
Schistosomiasis Vaccine: Research to Development
Due to their worldwide importance for human and animal health, schistosomes are in the focus of national and international research activities. Schistosomiasis is a major health problem and despite decades of research, only one effective drug, Praziquantel is currently available. Recent expansion of sequence databases on Schistosoma mansoni and S. japonicum has permitted a wealth of novel prote...
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The undisputed, worldwide success of chemotherapy notwithstanding, schistosomiasis continues to defy control efforts in as much rapid reinfection demands repeated treatment, sometimes as often as once a year. There is thus a need for a complementary tool with effect for the longer term, notably a vaccine. International efforts in this direction have been ongoing for several decades but, until t...
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Schistosomiasis, caused by three principal species of diecious trematodes (flatworms), currently afflicts over 250 million individuals, results in an estimated 2-15% chronic disability, and contributes to poor health and economic stagnation in endemic areas. Although schistosomiasis is effectively treated with praziquantel, rapid reinfection with rebound morbidity precludes effective control ba...
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Schistosomiasis is a neglected tropical disease of humans, and it is considered to be the second most devastating parasitic disease after malaria. Eggs produced by normally developed female worms are important in the transmission of the parasite, and they responsible for the pathogenesis of schistosomiasis. The tumor suppressor gene lethal giant larvae (lgl) has an essential function in establi...
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ژورنال
عنوان ژورنال: Expert Review of Vaccines
سال: 2016
ISSN: 1476-0584,1744-8395
DOI: 10.1586/14760584.2016.1131127